The present study involves the formulation and evaluation of buccal films of ondansetron HCl using HPMC K15M, eudragit RL-100 and chitosan in various proportions and combination. The films were fabricated by solvent casting method using. Ondansetron hydrochloride, an antiemetic drug has oral bioavailability of 60% due to hepatic first metabolism and a short half-life of 5 hrs. Buccal route is an excellent alternative method for the systemic delivery that can improve the bioavailability. A significant reduction in dose and dosing frequency can be achieved with prolonged duration of action, thereby improving the patient compliances. The formulations F1-F11 were evaluated for physicochemical parameter like weight variation, thickness, folding endurance, drug content uniformity, swelling index, surface pH and mucoadhesion time in addition to in-vitro drug release and in-vitro permeation studies. All the formulations sustained the release upto 12 hrs with F2 exhibiting best release pattern. The investigation concluded that F2 containing Eudragit RL-100 and HPMC K15M was best formulation which follows the zero order kinetic with R2 value 0.970. Treatment via buccal route offer many advantages in comparison to traditional treatments and can be proposed as a new therapeutic tool.
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